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MK-3207 (Hydrochloride)
CAS No. 957116-20-0
MK-3207 (Hydrochloride) ( MK3207 Hydrochloride;MK 3207 Hydrochloride;MK-3207 )
Catalog No. M16836 CAS No. 957116-20-0
A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 126 | Get Quote |
|
| 10MG | 230 | Get Quote |
|
| 25MG | 390 | Get Quote |
|
| 50MG | 627 | Get Quote |
|
| 100MG | 896 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMK-3207 (Hydrochloride)
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.
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DescriptionA highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay; displays >50000-fold selectivity in a panel of 160 enzymes, receptors, channels, and 65-fold more potent than telcagepant; orally bioavailable.
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SynonymsMK3207 Hydrochloride;MK 3207 Hydrochloride;MK-3207
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PathwayGPCR/G Protein
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TargetCGRP Receptor
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RecptorCGRP
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number957116-20-0
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Formula Weight594.05
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Molecular FormulaC31H30ClF2N5O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CCC2(C1)C(=O)N(C(CN2)C3=CC(=CC(=C3)F)F)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4.Cl
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Chemical Name6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride (1:1), (8R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bell IM, et al. ACS Med Chem Lett. 2010 Jan 12;1(1):24-9.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
3. Li CC, et al. Br J Clin Pharmacol. 2015 May;79(5):831-7.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
3. Li CC, et al. Br J Clin Pharmacol. 2015 May;79(5):831-7.
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