Cart
sales@molnova.com
Home - Products - GPCR/G Protein - CGRP Receptor - MK-3207 (Hydrochloride)

MK-3207 (Hydrochloride)

CAS No. 957116-20-0

MK-3207 (Hydrochloride) ( MK3207 Hydrochloride;MK 3207 Hydrochloride;MK-3207 )

Catalog No. M16836 CAS No. 957116-20-0

A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 126 Get Quote
10MG 230 Get Quote
25MG 390 Get Quote
50MG 627 Get Quote
100MG 896 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    MK-3207 (Hydrochloride)
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.
  • Description
    A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay; displays >50000-fold selectivity in a panel of 160 enzymes, receptors, channels, and 65-fold more potent than telcagepant; orally bioavailable.
  • Synonyms
    MK3207 Hydrochloride;MK 3207 Hydrochloride;MK-3207
  • Pathway
    GPCR/G Protein
  • Target
    CGRP Receptor
  • Recptor
    CGRP
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    957116-20-0
  • Formula Weight
    594.05
  • Molecular Formula
    C31H30ClF2N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CCC2(C1)C(=O)N(C(CN2)C3=CC(=CC(=C3)F)F)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4.Cl
  • Chemical Name
    6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride (1:1), (8R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bell IM, et al. ACS Med Chem Lett. 2010 Jan 12;1(1):24-9.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
3. Li CC, et al. Br J Clin Pharmacol. 2015 May;79(5):831-7.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • MK-8825

    MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.

  • Calcitonin (human)

    Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.

  • α-CGRP (human)

    Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.

Sign In Join Free